Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

This study used a partial least squares structural equation modelling (PLS-SEM) to estimate curriculum management's direct and indirect effects on university graduate programmes' viability. The study also examined the role of institutional effectiveness in mediating the nexus between the predictor and response variables. This is a correlational study with a factorial research design. The study's participants comprised 149 higher education administrators (23 Faculty Deans and 126 HODs) from two public universities in Nigeria. A structured questionnaire designed by the researchers was (...) used for data collection. The questionnaire was duly validated with an acceptable scale and item content validity indices. The dimensionality of the instrument was determined using exploratory factor analysis (EFA). Convergent validity was based on Average Variance Extracted (AVE), whereas discriminant validity was based on Fornell-Lacker criteria and the Hetero-Trait Mono-Trait (HTMT) ratio. Acceptable composite reliability estimates of internal consistency were reached for the three sub-scales. Following ethical practices, the questionnaire was physically administered to respondents and retrieved afterwards. Smart PLS (version 3.2.9) and SPSS (version 26.0) programs were used for all the statistical analyses. This study uncovered significant direct and indirect effects of curriculum management on the viability of graduate programmes. Institutional effectiveness significantly impacted graduate programmes’ viability while mediating the nexus between curriculum management and graduate programmes’ viability. Curriculum management and institutional effectiveness jointly explained a significant proportion of graduate programmes’ viability variance. The result of this study proved that graduate programmes’ viability depends, to a great extent, on how much curriculum is managed and how effective institutions are with their services. The result of this study can enable institutions seeking to run viable graduate programmes to re-evaluate their curriculum management practices and the effectiveness of their services. (shrink)

An account of the three rival conceptions of Western philosophy: "theoretical," "difference," and "practical." -/- Posted 29 January 2023. Note that a previous version of this paper appears as chapter 13 of my Patriotic Elaborations: Essays in Practical Philosophy (Montreal and Kingston: McGill-Queen’s University Press, 2009).

The meanings and functions of the notion of social philosophy in John Dewey’s writings have not really been subjected to serious philological investigation. Until recently, Dewey scholarship has simply equated social philosophy either to political philosophy in general, or to philosophy of education,1 and in recent years we have tended to read this social philosophy from a retrospective point of view, with reference to contemporary debates about social philosophy as an alternative to contemporary political philosophy.2 One reason for this lack (...) of philological attention has been that the only way to study Dewey’s project of social philosophy was to refer to the English translation of the Chinese translation... (shrink)

Edition du ms. K 861 découvert à la Bibliothèque humaniste de Sélestat, dans lequel Beatus Rhenanus, étudiant alsacien de Jacques Lefèvre d’Etaples et de Charles de Bovelles de 1503 à 1505, rapporte un propos de ce dernier, réunit un ensemble de citations de Nicolas de Cues, et transcrit un opuscule inédit de 62 propositions Sapiens est qui se fecit hominem, que l’on peut attribuer à Bovelles.

Cet article se propose de mettre en perspective les débats actuels en distinguant tout d’abord deux types de critiques de la sociologie critique : celles qui opposent sociologies critiques et non critiques, et celles qui relèvent de controverses internes à la sociologie critique. Dans l’une et l’autre de ces types de controverses, l’idée de sociologie est entendue en un sens réducteur. Il semble utile de souligner la diversité des définitions, des justifications et des modèles critiques propres aux différentes formes possibles (...) de la sociologie critique. La première section de l’article porte sur la question de la définition, la deuxième sur celle des justifications, et la troisième sur celle des effets critiques. (shrink)

Bien que les traités de Charles de Bovelles de 1511, qui comprennent le Livre du sage, ne mentionnent pas la métaphysique dans leur titre, ses écrits antérieurs de l’année 1504 portent explicitement sur des questions métaphysiques. En outre, nous pouvons observer une continuité évidente entre ces premières pensées et les écrits ultérieurs du volume de 1511. Dans cette perspective, nous publions ici pour la première fois la traduction française, avec l’original latin, du chapitre 7 de l’ Introduction métaphysique, et (...) du chapitre 5 de l’ Opuscule des notions communes qui regardent la métaphysique. (shrink)

Review on Cicero, On Academic Scepticism, translated with introduction and notes by Charles Brittain, Hackett, Indianapolis and Cambridge, 2006.

Kant's revolution in methodology limited metaphysics to the conditions of possible experience. Since, following Hume, analysis—the “method of discovery” in early modern physics—could no longer ground itself in sense or in God's constituting reason a new arché, “origin” and “principle,” was required, which Kant found in the synthesis of the productive imagination, the common root of sensibility and understanding. Charles Bigger argues that this imaginative “between” recapitulates the ancient Gaia myth which, as used by Plato in the Timaeus, offers (...) a way into this originary arché. Since it depends on myth and the “likely story” rather than on a self-certain apprehension of Being, this facilitates an imaginative approach to the natural sciences which, through its synthetic a priori formations, can claim to be Kantian. Bigger explores Kant's ethics as an alternative to metaphysics that holds open the prospect of a Good beyond Being—and phenomenology—whose traces nevertheless appear in original synthesis. Though wary of its reductive implications, Bigger uses Derrida's difference, a medial, feminine arché, as a way into this creative and procreative metaxu. As Emmanuel Levinas suggests, this is Plato's gap [chaos] between being and becoming, whose possibility, beyond both, lies in chora and the Good. This Open also presents the possibility for a new, yet still Kantian, understanding of the formal and material conditions for the natural sciences. (shrink)

For Plotinus, the human face is that part of the body where the light of intelligibility can be shown through in the best way. It is why the face is beautiful, and, for this reason, it can be compared to the most beautiful things of the world. The stars, for example. But an issue raises immediately: when the face is compared to things of beauty, is not the actual meaning of the human face that could be lost? This question can (...) be thought again in the Christian world, and also, thanks to Emmanuel Levinas, in the contemporary philosophy. (shrink)

Solidarity is crucial for realizing justice, securing public goods, and reducing domination. Yet there have been few theoretical studies of its threats and vulnerabilities. In this paper I fill this lacuna, outlining four approaches to what undermines solidarity and considering their implications for contemporary political theory. I begin by reviewing the empirical literature on solidarity, noting that its focus on diversity and individuation has yielded inconclusive results. I then develop four alternative threats to solidarity by drawing from the history of (...) political thought, social theory, and religious studies: interpersonal dependence (Jean-Jacques Rousseau); radical evil (Immanuel Kant); self-dissolution (Émile Durkheim); and moral spectatorship (Emmanuel Levinas). Taking these threats into account, I conclude, should significantly impact our normative theorizing about solidarity. In particular, it should encourage a research agenda that attends to solidarity’s affective, esthetic, and non-rational sources. (shrink)

This paper explores Luce Irigaray’s evaluation of Aristotle’s conception of place, and how it might connect to issues of ethnicity and race. The philosophy of Jacques Derrida and Emmanuel Levinas suggest that emphasis and focus on differences might in some ways lead to a destruction of the individual. In the end, it will be recognized that maintaining difference is a relevant issue in creating proper sense of identity, as well as provide a basis for constructing a more inclusive, diverse, (...) and egalitarian ethical theory. (shrink)

The notion of the ‘division of physiological labour’ is today an outdated relic in the history of science. This contrasts with the fate of another notion, which was so frequently paired with the division of physiological labour, which is the concept of ‘morphological differentiation.’ This is one of the elementary modal concepts of ontogenesis. In this paper, we intend to target the problems and causes that gradually led biologists to combine these two notions during the 19th century, and to progressively (...) dissociate them, retaining only the concept of differentiation by the early 20th century. We shall adhere to the following: 1. The primitive economic concept of the division of labour is not a descriptive notion denoting a type of organisation of labour, but an etiological one: the idea of a causal relationship between this type of organization and the improvement of the whole. 2. This concept rapidly interested naturalists such as Henri Milne-Edwards, who were keen to find a rational ground for hierarchizing living forms based on anatomical complexity. 3. The validation of this notion in the realms of biology was subject to at least two conditions which were far from being fully satisfied. This did not prevent, however, the initial success of the concept of the division of physiological labour during the second half of the 19th century. 4. Finally, the gradual disqualification, within the Darwinian theoretical context, of the conception of an intrinsic hierarchical rank of organisms, led to a lack of interest in the concept of the physiological division of labour, at least in its non-Darwinian and non-ecological variant (the link between the division of labour within an organism and organic perfection). (shrink)

Papers based on the work of Emmanuel Levinas' account of the face of the other.

In behavioral ethics today, there is debate as to which theory of moral development is the best for understanding ethical decision making, thereby facilitating ethical behavior. This debate between behavioral ethicists has been profoundly influenced by the field of moral psychology. Unfortunately, in the course of this marriage between moral psychology and business ethics and subsequent internal debate, a simple but critical understanding of human being in the field of management has been obscured; i.e., that morality is not a secondary (...) phenomenon arising out of something else. Therefore, in this paper, we will argue that there is a need in behavioral ethics to shift our understanding away from the influence of contemporary moral psychology and back to management theorist Ghoshal’s :75–91, 2005) view of what it means to be human in which the moral is fundamental. To assist in this labor, we will build on the philosophical work of Emmanuel Levinas who sees ethics, regardless of the setting, as a metaphysical concern. What this means is that Levinas sees the essential moral character of human life and the reality of human agency as ontologically fundamental, or constitutive of human nature itself. In other words, the ethical is the “first cause” in regard to understanding the nature and action of the individual, including within organizations. Thus, morality in any sphere of human endeavor, including in business, is not merely epiphenomenal to some more fundamental reality. (shrink)

The final section of the book considers two features of the world which transcend the categories, existence and negation.

Using the work of Emmanuel Levinas, this article sheds light on Charlie Chaplin's The Circus, a piece that so far eluded the critics, despite its immense popularity with theater viewers. I show that it is not Chaplin's lack of inventiveness that makes the Tramp risk his life on the tightrope 'for nothing'. It is, on the contrary, Chaplin's intuitive sense that makes him believe, anticipating Levinas, that it is human and simple for a person to help another for no (...) benefit. It is this point that cinema-goers understood more easily than we, scholars, may think. Starting with The Circus I demonstrate that this film, which critics have underestimated due to its 'pointless' ending, becomes meaningful once interpreted as promoting radical for-the-other ethics. My argument about The Circus is supported by close reading as well as Chaplin's own remarks and his later talkie Limelight in which similar ideas are expressed more openly through language and through the ending scene, with the protagonist dying on stage, to the sounds of roaring laughter of the audience. (shrink)

In The Origin of Species (1859) Darwin challenged many of the most deeply-held beliefs of the Western world. Arguing for a material, not divine, origin of species, he showed that new species are achieved by "natural selection." The Origin communicates the enthusiasm of original thinking in an open, descriptive style, and Darwin's emphasis on the value of diversity speaks more strongly now than ever. As well as a stimulating introduction and detailed notes, this edition offers a register of the many (...) writers referred to by Darwin in the text. (shrink)

Originally published in 1992. The history of Western philosophy can be seen as a battle between those that insist that the "physical universe" exists and those would claim that there is a much larger "world" which contains atemporal and nonspatial things as well. The central part of this book, and the battle, concerns the existence of universals. Starting with the mediaeval definition of the issue found in Porphry and Boethius, the author then considers modern and contemporary versions of the battle. (...) He concludes that what is at stake between naturalists and ontologists is the existence and nature of a number of important categories, like structures, relations, sets, numbers and so on. (shrink)

Certain questions have recurred throughout the history of philosophy. They are the big questions-about happiness and the good life, the limits of knowledge, the ultimate structure of reality, the nature of consciousness, the relation between causality and free will, the pervasiveness of suffering, and the conditions for a just and flourishing society-that thinkers in different cultures across the ages have formulated in their own terms in an attempt to make sense of their lives and the world around them. The essays (...) in this book turn to the major figures and texts of the Buddhist tradition in order to expand and enrich our thinking on these enduring questions. Examining them from a comparative and cross-cultural perspective demonstrates the value of alternative ways of addressing philosophical problems, showing how different approaches can produce new and unexpected kinds of questions and answers. Engaging with the Buddhist tradition, this book shows, helps return philosophy to its practical as well as theoretical aim: not only understanding the world but also knowing how to live in it. Featuring striking and generative comparisons of Buddhist and Western thought, Philosophy's Big Questions challenges our thinking in fundamental ways and offers readers new conceptual tools, methods, and insights for the pursuit of a good and happy life. (shrink)

This is a major and comprehensive study of the philosophy of Hegel, his place in the history of ideas, and his continuing relevance and importance. Professor Taylor relates Hegel to the earlier history of philosophy and, more particularly, to the central intellectual and spiritual issues of his own time. He engages with Hegel sympathetically, on Hegel's own terms and, as the subject demands, in detail. This important book is now reissued with a fresh new cover.

Emmanuel Levinas is one of the most important figures of twentieth-century philosophy. Exerting a profound influence upon such thinkers as Derrida, Lyotard, Blanchot, and Irigaray, Levinas's work bridges several major gaps in the evolution of continental philosophy--between modern and postmodern, phenomenology and poststructuralism, ethics and ontology. He is credited with having spurred a revitalized interest in ethics-based philosophy throughout Europe and America. _Entre Nous_ (Between Us) is the culmination of Levinas's philosophy. Published in France a few years before his (...) death, it gathers his most important work and reveals the development of his thought over nearly forty years of committed inquiry. Along with several trenchant interviews published here, these essays engage with issues of suffering, love, religion, culture, justice, human rights, and legal theory. Taken together, they constitute a key to Levinas's ideas on the ethical dimensions of otherness. Working from the phenomenological method of Edmund Husserl and Martin Heidegger, Levinas pushed beyond the limits of their framework to argue that it is ethics, not ontology, that orients philosophy, and that responsibility precedes reasoning. Ethics for Levinas means responsibility in relation to difference. Throughout his work, Levinas returns to the metaphor of the face of the other to discuss how and where responsibility enters our lives and makes philosophy necessary. For Levinas, ethics begins with our face to face interaction with another person--seeing that person not as a reflection of one's self, nor as a threat, but as different and greater than self. Levinas moves the reader to recognize the implications of this interaction: our abiding responsibility for the other, and our concern with the other's suffering and death. Situated at the crossroads of several philosophical schools and approaches, Levinas's work illuminates a host of critical issues and has found resonances among students and scholars of literature, law, religion, and politics. _Entre Nous_ is at once the apotheosis of his work and an accessible introduction to it. In the end, Levinas's urgent meditations upon the face of the other suggest a new foundation upon which to grasp the nature of good and evil in the tangled skein of our lives. (shrink)

The present edition provides a detailed and accessible discussion ofhis theories and adds an account of the immediate responses to the book on publication.

Discusses contemporary notions of the self, and examines their origins, development, and effects.

The paradoxical logic of transparency and mediation Transparency is the metaphor of our time. Whether in government or corporate governance, finance, technology, health or the media – it is ubiquitous today, and there is hardly a current debate that does not call for more transparency. But what does this word actually stand for and what are the consequences for the life of individuals? Can knowledge from the arts, and its play of visibility and invisibility, tell us something about the paradoxical (...) logics of transparency and mediation? This Obscure Thing Called Transparency gathers contributions by international experts who critically assess the promises and perils of transparency today. (shrink)